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Technical University of Munich

Biomolecular Engineering & Design

Research on the physics of self-organization in biology. Image: Stefan Woidig / TUM

Based on a quantitative understanding of biomolecular interactions as well as modern AI tools, we use nucleic acid nanotechnology and protein design to create a new level of sophistication in biomolecular design. Our goals range from controlling molecular self-organization to recreating life from the bottom up, and programming cells for sensing, computation, actuation and therapeutics.

Subtopics

  • DNA Origami
  • Molecular Machines
  • Dynamic Molecular Structure

  • Protein Science, Evolution & Design
  • Functional Dynamics

  • Molecular Feedback Cycles
  • Cellular Model Systems
  • Multicellular Systems

News - Biomolecular Engineering & Design

BioSysteM, Biomolecular Engineering & Design, Research, Bioscience |

A tattoo as a biosensor

At the iGEM competition in Paris, high school and collegiate teams from around the world compete against one another with their synthetic biology…

BNMRZ, Public Outreach, CRC, CPA, Bioscience, Chemistry, Physics |

TUM Open Campus Day in Garching

Insights into studying and research at NAT for prospective students

Fundamental Science for Health, CPA, Research, Bioscience |

Hope for Preventing Stomach Cancer

New Drug Candidate Extremely Effective Against H. pylori Bacterium

BioSysteM, Biomolecular Engineering & Design, Accelerated Scientific Discovery, Bioscience |

Designing proteins for targeted cell activation

NewIn: Thomas Schlichthärle

Public Outreach, Diversity, CRC, CPA, Bioscience, Chemistry |

Women in Chemistry Event on February 25, 2026

Networking of doctoral and postdoctoral researchers in chemistry

MIBE, Physics, Award |

Prof. Franz Pfeiffer receives honorary professorship at Tsinghua University

Franz Pfeiffer, Professor of Biomedical Physics at the Technical University of Munich (TUM) and Director of the Munich Institute of Biomedical…

Biomolecular Engineering & Design, CPA, Bioscience |

Inaugural Lecture: Prof. Thomas Schlichthärle

On December 5, 2025, new TUM Department of Bioscience professor gave an introductory lecture at the Center for Protein Assemblies (CPA).

Biomolecular Engineering & Design, CPA, Research, Bioscience |

You’ve got mail: Nuclei function as carrier pigeons enhancing communication within multinucleate cells

Prof. Karen Alim and team have unraveled a new mechanism of signal transduction within large, multinucleated cells.

BioSysteM, Fundamental Science for Health, Fundamental Forces and Cosmic Evolution, Biomolecular Engineering & Design, ERC, ORIGINS, Research, Bioscience, Physics, Award |

Six ERC Consolidator Grants awarded to TUM researchers

EU funding for projects in biotechnology, medicine, and physics. Karoline Schäffner, Danny Nedialkova, Karen Alim and Roberto Rizzato from NAT are…

Biomolecular Engineering & Design, Research, Bioscience |

Lipid-inspired DNA Origami Creates Programmable Containers for Biomolecular Robotics

New “Dipid” structures combine lipid assembly principles with DNA programmability, enabling customizable containers for synthetic biology and…

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