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Technical University of Munich

Biomolecular Engineering & Design

Research on the physics of self-organization in biology. Image: Stefan Woidig / TUM

Based on a quantitative understanding of biomolecular interactions as well as modern AI tools, we use nucleic acid nanotechnology and protein design to create a new level of sophistication in biomolecular design. Our goals range from controlling molecular self-organization to recreating life from the bottom up, and programming cells for sensing, computation, actuation and therapeutics.

Subtopics

  • DNA Origami
  • Molecular Machines
  • Dynamic Molecular Structure

  • Protein Science, Evolution & Design
  • Functional Dynamics

  • Molecular Feedback Cycles
  • Cellular Model Systems
  • Multicellular Systems

News - Biomolecular Engineering & Design

BioSysteM, Biomolecular Engineering & Design, Research, Bioscience |

Programmable molecular machines are getting closer

Robust electrically controllable DNA switch developed

Biomolecular Engineering & Design, ORIGINS, Research, Bioscience |

More on life in a bubble: genetic content matters

NAT Prof. Job Boekhoven and Prof. Hannes Mutschler from the TU Dortmund demonstrate how the introduction of genetic material selectively affects even…

ERC, CPA, Bioscience, Award |

Five ERC grants awarded to TUM researchers

Proof of Concept grants for projects by Karen Alim and Matthias Feige from the Department of Bioscience at NAT.

Center for Smart Drug Design, Biomolecular Engineering & Design, CPA, Bioscience |

Inaugural lecture: Prof. Ana I. Benítez-Mateos

Prof. Ana I. Benítez-Mateos presented “Redefining cell-free biosystems for sustainable biocatalysis” as part of the CPA seminar series.

Fundamental Science for Health, Biomolecular Engineering & Design, MIBE, Research, Bioscience |

Reading Genetic Activity from Living Cells without Destroying Them

Tool for Better Control of Stem Cell Development

BioSysteM, Biomolecular Engineering & Design, Research, Bioscience |

A tattoo as a biosensor

At the iGEM competition in Paris, high school and collegiate teams from around the world compete against one another with their synthetic biology…

BNMRZ, Public Outreach, CRC, CPA, Bioscience, Chemistry, Physics |

TUM Open Campus Day in Garching

Insights into studying and research at NAT for prospective students

Fundamental Science for Health, CPA, Research, Bioscience |

Hope for Preventing Stomach Cancer

New Drug Candidate Extremely Effective Against H. pylori Bacterium

BioSysteM, Biomolecular Engineering & Design, Accelerated Scientific Discovery, Bioscience |

Designing proteins for targeted cell activation

NewIn: Thomas Schlichthärle

Public Outreach, Diversity, CRC, CPA, Bioscience, Chemistry |

Women in Chemistry Event on February 25, 2026

Networking of doctoral and postdoctoral researchers in chemistry

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